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The intestines are made up of one single layer of cells and these cells are connected by “tight junctions” that prevent passage of hazardous toxins from the gut and into the bloodstream. Gluten (gliadin) causes the tight junctions to come apart and allows toxins and food particles from the gut to reach the bloodstream, which leads to the immune system mounting an attack against the foreign and toxic particles.
This is leaky gut.
Now how people can say they “do fine” with gluten, I don’t understand because this phenomenon of tight junction disassembly happens in every single human and has been correlated with multiple autoimmune diseases, types 1 and 2 diabetes, obesity, food allergies, IBS, IBD, celiac disease, liver diseases, kidney diseases, skin problems, cancer, and a host of other pathologies. Check out the work of Dr. Alessio Fasano or google “Zonulin” for more info. And ditch the gluten!